The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalogue of perturbation-response signatures by utilizing a diverse collection of: Perturbations (e.g. chemical, genetic, disease state) Model Systems (e.g. cell lines, differentiated cells, embryonic stem cells) and Sssay Types (e.g. gene expression, protein expression,...
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Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Researchers from the Center for Computational Science (CCS) with their collaborators from Harvard, The Scripps Research Institute, and Yale have just published a study, "Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation" in the prestigious journal Nature that may lead to the development of novel, safer,...
Read MoreAssociate Scientist Dr. Dušica Vidović joined the Chemoinformatics team at CCS in September 2008. Before she joined, she was a Research Associate at The Scripps Research Institute and The Computer-Chemistry Centrum in the field of chemoinformatics. Dr. Vidović has experience in HTS data analysis, structure-based and ligand-based drug design, homology modeling, docking and scoring, virtual screening, pharmacophore modeling, lead...
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“Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand” was recently published in Nature International Weekly Journal of Science. We applaud Drs. Stephan Schurer and Dusica Vidovic on their contributions to the article. Click to access the article through the Nature website. Acknowledgements include NIH funding and the resources at the Center for Computational Science. (Click to download .pdf)...
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