Posts Tagged "Drug Discovery"



Stephan Schuerer Webinar:  Human vs. Machine-Enhanced Scientific Discovery

Join Mark Musen (Stanford), Janice Kranz and Stephan Schürer (University of Miami) for CDD’s Q3 Town Hall Webinar, “Human vs. Machine-Enhanced Scientific Discovery” Listen Here We’re seeing ‘Big Data’ everywhere: healthcare, business, sports, traffic control, biology, drug discovery. The ‘behind-the-scenes’ tool enabling the power of Big Data – searching, sharing, visualizing, querying, analyzing – is the Semantic Web (aka ‘Web...

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BD2K-LINCS Summer Research Training Program Has Begun

Summer Research Training Program in Biomedical Big Data Science Program Dates: June 1 - August 7, 2015 The 2015 Summer Research Training Program in Biomedical Big Data Science sponsored by the Big Data to Knowledge (BD2K) Data Coordination and Integration Center (DCIC) for the Library of Integrated Network-based Cellular Signatures (LINCS) is a research intensive ten-week training program offered at six sites affiliated with our...

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UM Awarded NIH Big Data to Knowledge (BD2K) Grant

Stephan Schürer, Ph.D., Associate Professor of Molecular and Cellular Pharmacology at the Miller School and Chemoinformatics Program Leader at CCS leads the team of University of Miami researchers funded through NIH  to create a Data Coordination and Integration Center for the Library of Integrated Network-based Cellular Signatures (LINCS) program. Read the NIH press release.  More on BD2K....

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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Summary of Study Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins cause IRE1α lumenal domain homo-oligomerization, inducing trans autophosphorylation that further drives homo-oligomerization of its cytosolic kinase/endoribonuclease (RNase) domains to activate mRNA splicing of adaptive XBP1 transcription factor. However,...

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A new version of the LIFE search engine has been released. LIFE makes it possible to search across data generated at the LINCS project.  This new release includes recent data releases from the LINCS Consortium. It has improved search functionality and several new data visualization features. LIFE is developed at the University of Miami LINCS Center under leadership of CCS Drug Discovery Program Director Dr. Stephan Schürer.  More...

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