Drug Discovery Research Archive



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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

ER stress triggers a “terminal UPR” via hyperactivation of IRE1α, an ER kinase/RNase

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Walking pathways and how promoters can help find new drugs

Walking pathways and how promoters can help find new drugs Alexander Kel, Ph.D. Chief Scientific Officer GeneXplain GmbH, Wolfenbuettel, Germany Institute of Systems Biology Ltd., Novosibirsk, Russia Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia Presented by: Alexander Kel, Ph.D. Thursday March 22nd, 2012, 12:00-1:00, CRB 692. Massive changes of expression of hundreds of […]

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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

“Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand” was recently published in Nature International Weekly Journal of Science. We applaud Drs. Stephan Schurer and Dusica Vidovic on their contributions to the article. Click to access the article through the Nature website. Acknowledgements include NIH funding and the resources at the Center for […]

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