Publications



‘Indignant Minnesotans’ remind journalists that data can hurt

Minnesotans got a bitter lesson on the limits of data this week when the Washington Post’s Wonkblog published a map ranking every county in the US by “scenery and climate.” Reporter Christopher Ingraham built the graphic with data from the 1999 “natural amenities index,” a list based on climate, topography, and water. The North Star state didn’t fare well, with all but two of its 87 counties rating low on the list. (Red Lake County...

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The push for open data has prompted the release of countless datasets. But the raw data alone can’t adequately serve the public. After all, it’s hard to imagine the average person investing the time—or possessing the skills—to make meaningful sense of a massive spreadsheet. That’s where the media comes in. Whenever possible, journalists should provide a way for every reader to explore the data and gain insights. Forget linking to...

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By Sawsan Khuri and Stefan Wuchty. BMC Bioinformatics 2015 Apr 1;16(1):109. [Epub ahead of print] PMID: 25880655   Abstract Background Minimum dominating sets (MDSet) of protein interaction networks allow the control of underlying protein interaction networks through their topological placement. While essential proteins are enriched in MDSets, we hypothesize that the statistical properties of biological functions of essential...

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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

Summary of Study Depending on endoplasmic reticulum (ER) stress levels, the ER transmembrane multidomain protein IRE1α promotes either adaptation or apoptosis. Unfolded ER proteins cause IRE1α lumenal domain homo-oligomerization, inducing trans autophosphorylation that further drives homo-oligomerization of its cytosolic kinase/endoribonuclease (RNase) domains to activate mRNA splicing of adaptive XBP1 transcription factor. However,...

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Tiered data storage addressed in HPCWire White Paper

University of Miami Center for Computational Science researchers published a White Paper in the latest issue of HPCwire on its unique tiered data storage system designed to address the burgeoning amounts of research data that address some of the world's biggest and most complex issues. Data in Motion - A New Paradigm in Research Data Lifecycle Management presents the complex set of interrelated challenges to managing ever-growing data...

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New Publication in NATURE

Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation Researchers from the Center for Computational Science (CCS) with their collaborators from Harvard, The Scripps Research Institute, and Yale have just published a study, "Anti-diabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation" in the prestigious journal Nature that may lead to the development of novel, safer,...

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